Third Bosses on each Node have a special permanent {{Perma support that gives extra abilities. These permanent supports affect both players. Third Node Bosses are: 1.3 Admiral Beckett Brass - Pirates 2.3 Zacama, Primal Scream - Dinosaurs 3.3 Kumena, Tyrant of Orazca - Merfolk}}

{{Perma support|name==== Admiral Becket Brass Permanent Node - Dead Men Tell no Tales ====<small>(see bugs)</small>{| classside="wikitable"both|+effect=</small>! colspan="2" |Node Effect: Permanent Support (both players) * see bugs|-<small>'''''{{Symbol|R}} Red|:''' Whenever you match 4 or more Red gems, destroy a block of 3x3 gems.''</small>* <small>'''''{{Symbol|-|U}} Blue|:''' Whenever you match 4 or more Blue gems, draw a card.''</small>* <small>'''''{{Symbol|-|B}} Black|:''' Whenever you match 4 or more Black gems, deal 3 damage to your opponent Planeswalker.''</small>|-|* <small>'''''5 Gems|:''' Whenever you match 5 or more gems, gain control of your opponent's first creature and give it '''Haste'.''|}}

{{Perma support|name==== Zacama Permanent Node - Primal Hunt ====During the boss fight, activated gems <small>(Red, Green and Whitesee bugs) will grant special benefits for each player's Dinosaurs, while harming their opponent's strategy.</small>{| classside="wikitable"both|+effect=</small>* <small>'''''{{Symbol|R}} Activate 1 Red:''' If you have a dinosaur in play:! colspan="2" |Node Effect: Permanent Support (both players) * see bugs|-|Activate 1 Red|Deal , deal 3 damage to your opponent's first creature. Your Dinosaurs gain '''Beserker''' and '''Trample''' until the end of turn.''</small>* <small>'''''{{Symbol|-|W}} Activate 1 White|Wain :''' If you have a dinosaur in play, gain 3 life. Your dinosaurs gain '''Vigilance''' and '''Regenerate 3''' until the beginning of your next turn. '' (see bugs)</small>*See Bugs|-<small>'''''{{Symbol|G}} Activate 1 Green|Destroy :''' If you have a dinosaur in play, destroy a non-land support your opponent controls. Your Dinosaurs get +1/+1''|}}

{{Perma support|name==== Kumena, Tyrant of Orazca Permanent Node - Call of Kumena ====During the boss fight, casting creatures, spells and drawing cards will create cyclical benefits by reducing mana costs, empowering creatures and increasing the speed of the battle.<small>(see bugs)</small>{| classside="wikitable"both|+effect=</small>!Node Effect: Permanent Support (both players) * see bugs|-|<small>''Whenever your draw a card, all cards in your hand gain 1 mana.''</small>|-|* <small>''Whenever a creature enters the battlefield, draw a card.''</small>|-|* <small>''Whenever you cast a spell, your first creature gets +1/+1.''|}}