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[[Core Set 2021]] is the 25th expansion set of [[Magic: the Gathering Puzzle Quest]], released in July 2020 in version 4.4 of the game. The set abbreviation is M21, and the set icon ({{SetSymbol|M21}}) is a stylized representation of the set abbreviation.

[[A Timeless Voyage]] (ATV) is a [[Coalition]] [[PvP]] event released at the same time. Unlike many events, its objectives' requirements feature no elements of its associated set. ATV therefore was able to remain Standard even when M21 became [[Legacy]] in October 2021.

[[Basri Ket]], [[Chandra, Heart of Fire]], [[Garruk, Unleashed]], [[Liliana, Waker of the Dead]] and [[Teferi, Master of Time]] are [[Planeswalkers]] released with M21.